Weight Gain Prevention Drug Fails In Trial

A story in the Globes just announced the failure of a drug being developed to prevent the weight gain associated with atypical neuroleptic drugs to do any better than a placebo, Obecure obesity drug fails trial.

Histalean was given in combination with Eli Lilly’s (NYSE: LLY) antipsychotic drug, Zyprexa, which is known to cause weight gain. In previous trials, Obecure was able to show that patients taking Zyprexa gained less weight when also taking Histalean than when taking Zyprexa alone.

Get that, gained less weight. Such was in the past, but more recently:

In the current trial using a higher dosage of Histalean, Obecure was unable to repeat the results.

Bio-light, the company developing Histalean, is repeating trials with a lower dosage to see if dosage might be at the root of this failure.

Eli Lilly, which partly financed the first trial of Histalean, on the grounds that ameliorating the side effects of Zyprexa would help product sales, is no longer involved in Histalean.

If you have any knowledge about this issue, you are probably aware that obesity is only one of a number of ill health conditions associated with a metabolic syndrome caused by the newer atypical neuroleptic drugs of which Zyprexa is an example. This metabolic syndrome has been credited with being the chief reason people in mental health treatment are dying on average 25 years earlier than the rest of the population.

Have we got a better argument for advancing methods of treatment that don’t involve the use of neuroleptic drugs, atypical or otherwise!? Well, actually, we do. Some studies have indicated that these drugs are at best ineffective, and at worst impeditive, if not preventive, to the process of complete recovery from serious life crises.

If there’s a lesson to be learned here it’s that health and fitness can’t be found in a pill bottle. Of course, this is a lesson some people are lax to pick up as it would jeopardize the enormous profit making power of pharmaceutical companies.

4 Responses

  1. Type II diabetes… metabolic syndrome… premature death…

    And pill is supposed to offset these things?
    Yeah, right…. Give me a break!

    What about the other “effects” of drugs like Zyprexa?

    (For all you NAMI folks, these are “effects” not side effects, and “drugs” not medications!…. They have been for years… You folks have ignored the facts!)

    What about the effects related to the brain function?

    What about the effect of shutting down the higher functioning of the brain?
    What about the effect of turning a human being into a zombie, huh?

    Is Pharma gonna find a pill for that?

    It’s time for the recovery model to really take root, with peer-run respites, and integrative forms of counseling and real medicine!

    Pharma and NAMI had their chance.
    They’ve caused enough injury and death.

    It’s time for treatment options that offer real hope!

    Duane Sherry, M.S.
    Discover and Recover: Resources for Mental and Overall Wellness

    • I had a surprise reaction to the idea of this drug, too, but I imagine it was to be expected. Biological medical model psychiatry has one primary form of treatment, or “management”, and that’s the drug.

      Considering effects as side-effects comes from the mistaken belief that these neuroleptic drugs were developed expressly to treat schizophrenia and, therefore, any unwanted effect must be a “side-effect”. Actually, these drugs were used as pesticides and anesthetics before they were ever used to treat the “mental illness” label. The drugs directly affect movement and coordination, emotional expression, and cognition. Those effects are direct effects, there is nothing side about them.

      I’m for more than any false hope, but peer run operations, crisis respite centers, and more integrative forms of treatment do constitute a much more positive direction to take. What’s certain is that biological medical model non-recovery treatment doesn’t have good outcomes, and those good outcomes are what we need.

  2. Crisis respite centers can be pretty medical model too. They are in Virginia. Depends who is running them.

    • When I mentioned crisis respite centers, I meant, of course, peer-run crisis respite centers. I am not, to my knowledge, aware of any in Virginia. There is one, er, three really, in West Virginia. The National Empowerment Center has an easily accessible pdf on the subject, Mental Health Peer Operated Crisis Respite Programs. It mentions programs in New Hampshire, Maine, Georgia, New York, Ohio, West Virginia, Alaska, and Nebraska. I have personally visited the Georgia Peer Support And Wellness Center in Decatur, Georgia, and spoken with its director, Jayme Lynch. Members of a group I am involved in, MindFreedom Florida, hope to start a respite center modeled after the one in Georgia in southwest Florida. I haven’t heard tell of any being very medical model. Did you perhaps have some other kind of program in mind?

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